abstract：AIM:The aim of the study was to assess and compare the safety of antiarrhythmic drugs (AADs) in an unselected real-world population of patients with atrial fibrillation (AF). METHODS AND RESULTS:This is a study of all patients with diagnosed AF in the Swedish Patient register who filled a prescription for sotalol, ami...

journal_title：American heart journal

authors： Friberg L

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of ticagrelor in patients with ST-elevation myocardial infarction (STEMI) treated with fibrinolytic therapy remain uncertain. OBJECTIVES:The primary objective of the TicagRElor in pAtients with ST elevation myocardial infarction treated with Thrombolysis (TREAT) trial is to evaluate ...

journal_title：American heart journal

authors： Berwanger O,Nicolau JC,Carvalho AC,Jiang L,Goodman S,Nicholls SJ,Parkhomenko A,Averkov O,Tajer C,Malaga G,Kerr Saraiva JF,Fonseca F,Guimaraes HP,de Barros E Silva PGM,Damiani LP,Paisani DM,Lasagno CMR,Candido CT,Valei

更新日期：2018-08-01 00:00:00

abstract：:In older patients (70 ± 7 years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6 months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exercise oxygen consumption (14.9 ± 0.2 mL kg-1 min-1 versus 14.4 ...

journal_title：American heart journal

authors： Upadhya B,Brubaker PH,Morgan TM,Eggebeen JD,Jao GT,Stewart KP,Kitzman DW

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Transcatheter foramen ovale closure (TPC) has emerged as a potential treatment option for patients with cryptogenic strokes and persistent foramen ovale (PFO). However, previous randomized controlled trials could hardly demonstrate any benefit compared to medical treatment (Med-Tx). Recently new data have be...

journal_title：American heart journal

authors： Reinthaler M,Ozga AK,Sinning D,Curio J,Al-Hindwan HS,Bäckemo Johansson J,Jung F,Lendlein A,Rauch G,Landmesser U

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) is a recently recognized condition where biomarkers and prognosis are less well studied than in MI with obstructive coronary artery disease (MI-CAD). We therefore aimed to investigate the one-year prognostic value of high-sensitivity ...

journal_title：American heart journal

authors： Hjort M,Lindahl B,Baron T,Jernberg T,Tornvall P,Eggers KM

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Appropriate thromboprophylaxis for patients with atrial fibrillation or atrial flutter (AF) remains a national challenge. METHODS:We hypothesized that a shared decision-making interaction facilitated by an Atrial Fibrillation Shared Decision Making Tool (AFSDM) would improve patient knowledge about atrial f...

journal_title：American heart journal

authors： Eckman MH,Costea A,Attari M,Munjal J,Wise RE,Knochelmann C,Flaherty ML,Baker P,Ireton R,Harnett BM,Leonard AC,Steen D,Rose A,Kues J

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:To characterize patient profile and hemodynamic profile of those undergoing intra-aortic balloon pump (IABP) for cardiogenic shock and define predictors of hemodynamic failure of IABP support. BACKGROUND:Clinical characteristics of IABP support in cardiogenic shock not related to acute myocardial infarction...

journal_title：American heart journal

authors： Hsu S,Kambhampati S,Sciortino CM,Russell SD,Schulman SP

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Heart Failure (HF) is a common cause of hospitalization in older adults. The transition from hospital to home is high-risk, and gaps in transitional care can increase the risk of re-hospitalization and death. Combining health care services supported by meta-analyses, we designed the PACT-HF transitional ca...

journal_title：American heart journal

authors： Van Spall HGC,Lee SF,Xie F,Ko DT,Thabane L,Ibrahim Q,Mitoff PR,Heffernan M,Maingi M,Tjandrawidjaja MC,Zia MI,Panju M,Perez R,Simek KD,Porepa L,Graham ID,Haynes RB,Haughton D,Connolly SJ

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Although outcomes data on transcatheter aortic valve replacement (TAVR) and transcatheter mitral valve repair (Mitraclip) are available via the Transcatheter Valve Therapy (TVT) registry, dissemination of TVT data is often delayed. The Food and Drug Administration's Manufacturer and User Facility Device Expe...

journal_title：American heart journal

authors： Galper BZ,Beery DE,Leighton G,Englander LL

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:We compared efficacy and safety of short- (3 or 6 months) versus long-term (≥12 months) dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation, according to the presence of chronic kidney disease (CKD). METHODS:Patient-level pooled analysis was performed with 7242 patients (87.2% with ...

journal_title：American heart journal

authors： Hwang D,Park KW,Lee JM,Rhee TM,Hong MK,Jang Y,Valgimigli M,Colombo A,Gilard M,Palmerini T,Stone GW,Kim HS

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:The CPORT-E trial showed the noninferiority of nonprimary percutaneous coronary intervention (PCI) at hospitals without cardiac surgery on-site (SoS) compared with hospitals with SoS for 6-week mortality and 9-month major adverse cardiac events (MACE). However, target vessel revascularization (TVR) was incre...

journal_title：American heart journal

authors： Czarny MJ,Miller JM,Naiman DQ,Hwang CW,Hasan RK,Lemmon CC,Aversano T

更新日期：2018-03-01 00:00:00

abstract：:Chronic exposure to fine particulate matter (PM2.5) is accepted as a causal risk factor for coronary heart disease (CHD). However, most of the evidence for this hypothesis is based upon cohort studies in whites, comprised of either only males or females who live in urban areas. It is possible that many estimates of th...

journal_title：American heart journal

authors： Loop MS,McClure LA,Levitan EB,Al-Hamdan MZ,Crosson WL,Safford MM

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Many young investigators are interested in cardiovascular (CV) outcomes research; however, the current training experience of early investigators across the United States is uncertain. METHODS:From April to November 2014, we surveyed mentees and mentors of early-stage CV outcomes investigators across the Un...

journal_title：American heart journal

authors： Khazanie P,Al-Khatib SM,Wang TY,Crowley MJ,Kressin NR,Krumholz HM,Kiefe CI,Wells BL,O'Brien SM,Peterson ED,Sanders GD

更新日期：2018-02-01 00:00:00

abstract：:Oxygen has long been assumed beneficial for all ill and injured patients. However, hyperoxia may be harmful and aggravate myocardial injury such as that caused by myocardial infarction. We aimed to investigate if hyperoxia increases myocardial injury following direct current cardioversion compared with room air. METH...

journal_title：American heart journal

authors： Lauridsen KG,Schmidt AS,Adelborg K,Bach L,Hornung N,Jepsen SM,Deakin CD,Rickers H,Løfgren B

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The ability to return to work after infective endocarditis (IE) holds important socioeconomic consequences for both patients and society, yet data on this issue are sparse. We examined return to the workforce and associated factors in IE patients of working age. METHODS:Using Danish nationwide registries, w...

journal_title：American heart journal

authors： Butt JH,Kragholm K,Dalager-Pedersen M,Rørth R,Kristensen SL,Chaudry MS,Valeur N,Østergaard L,Torp-Pedersen C,Gislason GH,Køber L,Fosbøl EL

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Chocolate consumption has been inconsistently associated with risk of atrial fibrillation (AF). We investigated the association between chocolate consumption and risk of AF in Swedish adults from two cohort studies and conducted a meta-analysis to summarize available evidence from cohort studies on this topi...

journal_title：American heart journal

authors： Larsson SC,Drca N,Jensen-Urstad M,Wolk A

更新日期：2018-01-01 00:00:00

abstract：AIMS:Furosemide is commonly prescribed for symptom relief in heart failure (HF) patients. Although few data support the continuous use of loop diuretics in apparently euvolemic HF patients with mild symptoms, there is concern about safety of diuretic withdrawal in these patients. The ReBIC-1 trial was designed to evalu...

journal_title：American heart journal

authors： da Rosa PR,Rohde LE,Doebber M,Ribeiro ALP,Prado DP,Bertoldi EG,Figueiredo Neto JA,Kohler I,Beck-da-Silva L,Danzmann LC,Moura LZ,Rover M,Simões MV,Sant'Anna RT,Biolo A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Cardiac pacing can be challenging after a Fontan operation, and limited data exist regarding pacing in adult Fontan patients. The objectives of our study were to determine risk factors for pacing and occurrence of device-related complications (DRCs) and pacemaker reinterventions. METHODS:We performed a retr...

journal_title：American heart journal

authors： Egbe AC,Huntley GD,Connolly HM,Ammash NM,Deshmukh AJ,Khan AR,Said SM,Akintoye E,Warnes CA,Kapa S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Despite significant attention to resuscitation care by hospitals, national data on trends in the incidence and survival of patients with inhospital cardiac arrest (IHCA) are limited. OBJECTIVE:To determine trends and hospital-level variation in the incidence and outcomes associated with IHCA. In exploratory...

journal_title：American heart journal

authors： Bradley SM,Kaboli P,Kamphuis LA,Chan PS,Iwashyna TJ,Nallamothu BK

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The latest cholesterol guidelines have shifted focus from achieving low-density lipoprotein cholesterol (LDL-C) targets toward statin use and intensity guided by atherosclerotic cardiovascular disease (ASCVD) risk. METHODS:Statin use and intensity were evaluated in 5,905 statin-eligible primary or secondary...

journal_title：American heart journal

authors： Navar AM,Wang TY,Li S,Robinson JG,Goldberg AC,Virani S,Roger VL,Wilson PWF,Elassal J,Lee LV,Peterson ED

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Galectin-3, a β-galactoside binding lectin involved in important regulatory roles in adhesion, inflammation, immunity, and fibrosis, may be relevant to atrial fibrillation (AF) etiology. METHODS:We included 8,436 participants free of AF at baseline (1996-1998) and with measures of plasma galectin-3 from the...

journal_title：American heart journal

authors： Fashanu OE,Norby FL,Aguilar D,Ballantyne CM,Hoogeveen RC,Chen LY,Soliman EZ,Alonso A,Folsom AR

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Cell adhesion molecules are key regulators of atherosclerotic plaque development, but circulating levels of soluble fragments, such as intercellular adhesion molecule (sICAM-1) and vascular cell adhesion molecule (sVCAM-1), have yielded conflicting associations with atherosclerotic cardiovascular disease (AS...

journal_title：American heart journal

authors： Ren HY,Khera A,de Lemos JA,Ayers CR,Rohatgi A

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Protocols incorporating high-sensitivity troponin to guide decision making in the disposition of patients with suspected acute coronary syndromes (ACS) in the emergency department have received a lot of attention. Traditionally, patients with chest pain have required long periods of observation in emergency ...

journal_title：American heart journal

authors： Papendick C,Blyth A,Seshadri A,Edmonds MJR,Briffa T,Cullen L,Quinn S,Karnon J,Chuang A,Nelson AJ,Horsfall M,Morton E,Chew DP

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Device-detected subclinical atrial fibrillation (AF) refers to infrequent, short-lasting, asymptomatic AF that is detected only with long-term continuous monitoring. Subclinical AF is common and associated with an increased risk of stroke; however, the risk of stroke with subclinical AF is lower than for cli...

journal_title：American heart journal

authors： Lopes RD,Alings M,Connolly SJ,Beresh H,Granger CB,Mazuecos JB,Boriani G,Nielsen JC,Conen D,Hohnloser SH,Mairesse GH,Mabo P,Camm AJ,Healey JS

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Several non-vitamin K antagonist oral anticoagulant (NOAC) alternatives to warfarin are available for stroke prevention in atrial fibrillation (AF). We aimed to describe the factors associated with selection of NOACs versus warfarin in patients with new onset AF. METHODS:The ORBIT-AF II study is a national,...

journal_title：American heart journal

authors： Steinberg BA,Shrader P,Thomas L,Ansell J,Fonarow GC,Gersh BJ,Hylek E,Kowey PR,Mahaffey KW,O'Brien EC,Singer DE,Peterson ED,Piccini JP,Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Investigato

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:To examine the safety and efficacy of cangrelor in patients with single-vessel disease (SVD) and multi-vessel disease (MVD). BACKGROUND:Cangrelor, an intravenous, rapidly acting P2Y12 inhibitor, is superior to clopidogrel in reducing ischemic events among patients receiving percutaneous coronary intervention...

journal_title：American heart journal

authors： Abnousi F,Sundaram V,Yong CM,Prats J,Deliargyris EN,Stone GW,Hamm CW,Steg PG,Gibson CM,White HD,Price MJ,Généreux P,Desai M,Yang L,Ding VY,Harrington RA,Bhatt DL,Mahaffey KW

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:The Fontan operation results in a circulation that is dependent on low pulmonary vascular resistance to maintain an adequate cardiac output. Medical therapies that lower pulmonary vascular resistance may augment cardiac output and improve long-term outcomes. OBJECTIVES:This phase I/II clinical trial conduct...

journal_title：American heart journal

authors： Goldberg DJ,Zak V,Goldstein BH,Chen S,Hamstra MS,Radojewski EA,Maunsell E,Mital S,Menon SC,Schumacher KR,Payne RM,Stylianou M,Kaltman JR,deVries TM,Yeager JL,Paridon SM,Pediatric Heart Network Investigators.

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:The 2020 American Heart Association Impact Goal aims to improve cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular disease and stroke by 20%. A large step toward this goal would be to better understand and take advantage of the significant intersection between behavior an...

journal_title：American heart journal

authors： Bansilal S,Vedanthan R,Kovacic JC,Soto AV,Latina J,Björkegren JLM,Jaslow R,Santana M,Sartori S,Giannarelli C,Mani V,Hajjar R,Schadt E,Kasarskis A,Fayad ZA,Fuster V

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Achieving a therapeutic international normalized ratio (INR) before hospital discharge is an important inpatient goal for patients undergoing mechanical cardiac valve replacement (MCVR). The use of clinical algorithms has reduced the time to achieve therapeutic INR (TTI) with warfarin therapy. Whether TTI pr...

journal_title：American heart journal

authors： Arendt CJ,Hong JH,Daly RC,Scott C,Mehta RA,Bailey K,Pathak J,Pereira NL

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Apparent treatment-resistant hypertension (aTRH) is associated with an increased risk of adverse cardiovascular outcomes. We studied the frequency and intensity of care for aTRH among participants aged 65 years and older in the US-based REGARDS study linked with Medicare claims. METHODS:Blood pressure (BP) ...

journal_title：American heart journal

authors： Vemulapalli S,Deng L,Patel MR,Kilgore ML,Jones WS,Curtis LH,Irvin MR,Svetkey LP,Shimbo D,Calhoun DA,Muntner P

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The increasing burden of cardiovascular disease (CVD) in low- and middle-income countries is largely driven by the increasing prevalence of hypertension, diabetes, and tobacco use. We hypothesize that the utilization of community health workers (CHWs) to screen for and manage these 3 determinants of CVD in a...

journal_title：American heart journal

authors： Khetan A,Purushothaman R,Zullo M,Gupta R,Hejjaji V,Agarwal S,Mohan SK,Josephson R

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The APEX trial assessed the safety and efficacy of extended-duration thromboprophylaxis using betrixaban versus standard dosing of enoxaparin among hospitalized, acutely ill medical patients. The 80-mg betrixaban dose was halved to 40 mg among subjects with severe renal insufficiency and those receiving a co...

journal_title：American heart journal

authors： Gibson CM,Halaby R,Korjian S,Daaboul Y,Arbetter DF,Yee MK,Goldhaber SZ,Hull R,Hernandez AF,Lu SP,Bandman O,Leeds JM,Gold A,Harrington RA,Cohen AT,APEX Investigators.

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Optimal antithrombotic treatment after transcatheter aortic valve replacement (TAVR) is unknown and determined empirically. The direct factor Xa inhibitor rivaroxaban may potentially reduce TAVR-related thrombotic complications and premature valve failure. DESIGN:GALILEO is an international, randomized, ope...

journal_title：American heart journal

authors： Windecker S,Tijssen J,Giustino G,Guimarães AH,Mehran R,Valgimigli M,Vranckx P,Welsh RC,Baber U,van Es GA,Wildgoose P,Volkl AA,Zazula A,Thomitzek K,Hemmrich M,Dangas GD

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The purpose of this study is to assess incidence and risk factors for severe renal dysfunction in patients requiring oral anticoagulation to help guide initial drug choice and provide a rational basis for interval monitoring of renal function for patients prescribed non-vitamin K oral anticoagulants. METHOD...

journal_title：American heart journal

authors： Fanola CL,Mooney D,Cowan AJ,Ko D,Sisson EK,Henault LE,Tripodis Y,Hylek EM

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:We aim to validate the diagnostic performance of the first fully automatic, electronic heart failure (HF) identification algorithm and evaluate the implementation of an HF Dashboard system with 2 components: real-time identification of decompensated HF admissions and accurate characterization of disease char...

journal_title：American heart journal

authors： Cox ZL,Lewis CM,Lai P,Lenihan DJ

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Patients with diabetes mellitus (DM) experience higher rates of in-stent restenosis and greater benefit from drug-eluting stents implant at the time of percutaneous coronary intervention (PCI), necessitating prolonged dual anti-platelet therapy (DAPT). While DAPT reduces risk of ischemic events post-PCI, it ...

journal_title：American heart journal

authors： Grodzinsky A,Arnold SV,Wang TY,Sharma P,Gosch K,Jones PG,Bhatt DL,Steg PG,McGuire DK,Cohen DJ,Spertus JA,Chhatriwalla AK,Lind M,Graham G,Kosiborod M

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:l-arginine is a commonly consumed dietary conditional essential amino acid found in food items and supplements, which is closely related to asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). l-arginine is thought to increase nitric oxide and be cardioprotective, whereas ADMA and SDMA m...

journal_title：American heart journal

authors： Au Yeung SL,Lin SL,Lam HS,Schooling CM

更新日期：2016-12-01 00:00:00

abstract：AIMS:In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. METHODS AND RESULTS:In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36...

journal_title：American heart journal

authors： Rinnström D,Dellborg M,Thilén U,Sörensson P,Nielsen NE,Christersson C,Johansson B

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Contemporary use of dual antiplatelet therapy and consistency with guideline recommendations in acute coronary syndrome patients undergoing percutaneous coronary intervention (PCI) have not been well characterized. METHODS:The COAPT was a prospective, observational, multicenter, longitudinal study of patien...

journal_title：American heart journal

authors： Déry JP,Mehta SR,Fisher HN,Zhang X,Zhu YE,Welsh RC,Lavi S,Cieza T,Henderson MA,Lutchmedial S,Siega AJ,Cheema AN,Wong BY,Kokis A,Dehghani P,Goodman SG,Canadian Observational AntiPlatelet sTudy (COAPT) Investigators.

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:There are limited data assessing statin therapy in patients with nonobstructive coronary plaque on coronary computed tomography angiography (CCTA). METHODS:Two hundred six consecutive patients with mild noncalcified plaque on CCTA were enrolled in this multicenter prospective observational study. Subjects w...

journal_title：American heart journal

authors： Li Z,Hou Z,Yin W,Liu K,Gao Y,Xu H,Yu F,Ma Z,Yu W,Yang L,Lu B

更新日期：2016-10-01 00:00:00